Dinophysistoxin-1

Okadaic acid

Last updated at: April 15, 2024

Recommended name
Dinophysistoxin-1
Synonyms
35S-methylokadaic acid, Dinophysistoxin 1
Recommended acronym
DTX1
Abbreviation

Progenitors

Name
Dinophysis acuta
Note
Predominant OA-group toxin in
Name
Dinophysis caudata
Name
Dinophysis fortii
Note
Predominant OA-group toxin in D fortii from NW-USA
Name
Dinophysis miles
Name
Dinophysis ovum
Name
Dinophysis sacculus
Name
Dinophysis acuminata
Note
Predominant OA-group toxin in cultured strains from NW Pacific and NE + from Mid-Atlantic USA, but toxin content in NW strains over two orders of magnitude higher

Vector Species

No vector species registered

References

Ayache N, Bill BD, Brosnahan ML, Campell L, Deeds JR, Fiorendino JD, Gobler CJ, Handy SM, Harrington N, Kulis DM, McCarron P, Milles CO, Moore SK, Nagai S, Trainer VL, Wolny JL, Young CS, Smith, JL., 2023
Structure
Formula
C45H70O13
Exact mono-isotopic mass
818.48164
Molfile
Untitled ACS Document 1996-1 ChemDraw02162321472D 58 64 0 0 1 0 0 0 0 0999 V2000 -6.4847 -0.0011 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -6.4847 -0.8617 0.0000 C 0
Alternative molfiles
n/a
SMILES
OC([C@](C)(O)C[C@@H]1CC[C@@H](O)[C@@]2(O[C@H]([C@H](C)/C=C/[C@@H]3O[C@]4(CC[C@@H](O[C@H]([C@@H](O)C[C@H](C)[C@H]5O[C@@]6([C@H](C)CCCO6)CC[C@H]5C)C([C@H]7O)=C)[C@H]7O4)CC3)CC(C)=C2)O1)=O
Alternative SMILES
OC([C](C)(O)C[CH]1CC[CH](O)[C]2(O[CH]([CH](C)/C=C/[CH]3O[C]4(CC[CH](O[CH]([CH](O)C[CH](C)[CH]5O[C]6([CH](C)CCCO6)CC[CH]5C)C([CH]7O)=C)[CH]7O4)CC3)CC(C)=C2)O1)=O
InChi key
CLBIEZBAENPDFY-HNXGFDTJSA-N
Alternative InChi keys
n/a
InChi
InChI=1S/C45H70O13/c1-25-21-35(56-45(23-25)36(47)13-12-32(55-45)24-42(7,51)41(49)50)26(2)10-11-31-15-17-43(54-31)18-16-34-40(57-43)37(48)30(6)39(53-34)33(46)22-28(4)38-27(3)14-19-44(58-38)29(5)9-8-20-52-44/h10-11,23,26-29,31-40,46-48,51H,6,8-9,12-22,
Alternative InChis
Spectra available
True
Chem files
Certified
True
Certified links
    n/a
Non certified reference material
Unknown

Chemical analysis

Research
True
Standardized
Unknown
Validated
Unknown
Official
n/a

Structure recognition assays

Research
Unknown
Standardized
Unknown
Validated
Unknown
Official
n/a

Functional assays

Research
True
Standardized
Unknown
Validated
Unknown
Official
n/a

Animal assays

Research
True
Standardized
Unknown
Validated
Unknown
Official
n/a
Regulatory status
True

Go to HAEDAT events

Human toxic syndrome(s)
Diarrhetic Shellfish Poisoning
Organ system toxicity
Gastro-intestinal toxicity
Risk assessment
True
Molecular targets known
True
Molecular targets
Protein phosphatase 2A, Protein phosphatase 1
Toxic to aquatic animals
Unknown
TEF available
True
Notes
Philipp Hess
Contact
John Ramsdell
Contact
Christopher Miles
Contact
Mirjam Klijnstra
Contact
Beatriz Reguera
Contact